A biological membrane or bio-membrane is an enclosing or separating membrane that acts as a selectively permeable barrier within living things. Biological membranes, in the form of cell membranes, often consist of a phospholipid bi-layer with embedded, integral and peripheral proteins used in communication and transportation of chemicals and ions. Bulk lipid in membrane delivers a fluid matrix for proteins to rotate and laterally diffuse for physiological operation. Proteins are adapted to high membrane fluidity environment of lipid bi-layer with the presence of an annular lipid shell, consisting of lipid molecules bound firmly to surface of integral membrane proteins. The cellular membranes should not be confused with isolating tissues formed by layers of cells, such as mucous membranes and basement membranes.